|
KMID : 1118520210180010011
|
|
Psychiatry Investigation
2021 Volume.18 No. 1 p.11 ~ p.18
|
|
|
The Association of Blood-Based Inflammatory Factors IL-1β, TGF-β and CRP with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment
|
|
Park Jun-Kyung
Lee Kang-Joon
Kim Ji-Yeon
Kim Hyun
|
|
|
Abstract
|
|
|
Objective: Many patients suffer from dementia in its most common form, Alzheimer’s disease (AD). In this study, the levels of IL-1β, TGF-β and CRP, which are involved in the inflammatory response in Alzheimer’s disease and its mild cognitive impairment (MCI), were measured and analyzed.
Methods: Seventy nine subjects participated in this study (mean age: 75.56 years, female: 54.3%, AD: 26, MCI: 28, normal: 25). The overall cognitive function of the subjects and the severity of the disease stage were assessed using the Mini-Mental State Examination (MMSE-K), the Clinical Dementia Rating (CDR), the Global Deterioration Scale (GDS) and the Geriatric Depression Scale-Korean (GDS-K).
Results: It was observed that patients with AD had significantly higher levels of IL-1β and TGF-β than the patients with MCI and normal controls. In addition, the MCI group showed a statistically significantly higher TGF-β concentration than the normal group.
Conclusion: These results suggest that IL-1β and TGF-β may be useful biological markers for patients with Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
IL-1β, TGF-β, CRP, Alzheimer’s disease, Mild cognitive impairment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|