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KMID : 1120220110020010008
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Osong Public Health and Research Perspectives
2011 Volume.2 No. 1 p.8 ~ p.14
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Genotypic Characterization of Vibrio vulnificus Clinical Isolates in Korea
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Jeong Hye-Sook
Kim Jun-Young
Jeon Se-Mi
Park Mi-Sun
Kim Seong-Han
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Abstract
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Objectives: Vibrio vunificus is known to cause septicemia and severe wound infections in patients with chronic liver diseases or an immuno-compromised condition. We carried out the molecular characterization of V. vulnificus isolates from human Vibrio septicemia cases based on pulsed-field gel electrophoresis (PFGE) using NotI and SfiI.
Methods and Results: PFGE was used to characterize a total of 78 strains from clinical cases after NotI or SfiI digestion. The geographical distribution of PFGE patterns for the strains from the southern part of Korea, a high-risk region for Vibrio septicemia, indicated that the isolates from southeastern Korea showed a comparatively higher degree of homology than those from southwestern Korea.
Conclusions: We report the genetic distribution of V. vulnficus isolated from Vibrio septicemia cases during 2000?2004 in Korea. This method has potential use as a subspecies-typing tool for V. vulnificus strains isolated from distant geographic regions.
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KEYWORD
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molecular typing, PFGE, Vibrio vulnificus
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