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KMID : 1120220170080010047
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Osong Public Health and Research Perspectives
2017 Volume.8 No. 1 p.47 ~ p.53
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Detection of Integrons and Staphylococcal Cassette Chromosome mec Types in Clinical Methicillin-resistant Coagulase Negative Staphylococci Strains
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Hajiahmadi Fahimeh
Ghale Elham Salimi
Alikhani Mohammad Yousef
Mordadi Alireza
Arabestani Mohammad Reza
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Abstract
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Objectives: Integrons are thought to play an important role in the spread of antibiotic resistance. This study investigates class 1 and 2 integron-positive methicillin-resistant coagulase-negative staphylococci strains isolated in Iran and characterizes their patterns of antimicrobial resistance.
Methods: Hundred clinical isolates of coagulase-negative staphylococci were characterized for integron content and staphylococcal cassette chromosome mec (SCCmec) type.
Results: Sixteen isolates carried class 1 (intI1) integrons and four isolates carried class 2 (intI2) integrons. One resistance gene array was identified among the class 1 integrons (aadA1 cassette). The distribution of SCCmec types in 50 methicillin-resistant coagulase-negative staphylococci strains showed that SCCmec types III and V dominated among the tested strains.
Conclusion: This is the first report of methicillin-resistant coagulase-negative staphylococci strains that carry two mobile genetic elements, including class 1 and 2 integrons and SCCmec, in Iran.
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KEYWORD
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coagulase-negative staphylococci, integrons, staphylococcal cassette chromosome mec
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