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KMID : 1120220180090020050
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Osong Public Health and Research Perspectives
2018 Volume.9 No. 2 p.50 ~ p.58
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Treatment with Sofosbuvir and Daclatasvir (with or without Ribavirin) Improves Patient Reported Outcomes in Hepatitis C
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de Medeiros Lucas Pereira Jorge
Lima Mario Barreto Correa
Pires Marcia Maria Amendola
Maciel Alessandra Mendonca Almeida
Medeiros Renata Barboza Vianna
Donadel Mariana Derminio
Pereira Isabela Martins Becattini
Leao Fabio Marchon
Pires Luiz Eduardo Amorim Correa Lima
Rzetelna Helio
Brandao-Mello Carlos Eduardo
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Abstract
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Objectives: To evaluate the impact of 3 treatment regimens upon health-related quality of life and work productivity using patient-reported outcomes (PROs) in chronic hepatitis C infected patients: sofosbuvir (SOF) + daclatasvir (DCV); SOF + DCV + ribavirin (RBV); SOF + simeprevir (SMV).
Methods: 4 questionnaires were used to evaluate PROs before, during and after treatment: Short Form-36 (SF-36), Chronic Liver Disease Questionnaire (CLDQ) - hepatitis C virus (HCV), Work Productivity and Activity Index, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F).
Results: Of the global sample of 55 patients included in this study; SOF + DCV (n = 10); SOF + DCV + RBV (n = 29); SOF + SMV (n = 16) all had a statistically significant improvement in SF-36, CLDQ and FACIT-F scores during and post-treatment. No statistically significant differences in the PRO questionnaire values were observed between the distinct treatment regimens. The SOF and SMV patient groups presented higher mean PRO variations during and post-treatment, compared to the other groups: SF-36 functional capacity (16.1); SF-36 mental health (21.4); CLDQ activity (1.8); CLDQ emotional function (1.2); FACIT-F physical well-being (8.0); Total FACIT-F (21.6).
Conclusion: Treatment with SOF + DCV, with or without RBV, results in an improved PRO similar to treatment with SOF + SMV in chronic hepatitis C patients.
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KEYWORD
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antiviral agents, hepatitis C, patient reported outcome measures, quality of life
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