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KMID : 1120220210120050278
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Osong Public Health and Research Perspectives
2021 Volume.12 No. 5 p.278 ~ p.285
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The role of lipids in the pathophysiology of coronavirus infections
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Zandi Milad
Hosseini Parastoo
Soltani Saber
Rasooli Azadeh
Moghadami Mona
Nasimzadeh Sepideh
Behnezhad Farzane
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Abstract
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Coronaviruses, which have been known to cause diseases in animals since the 1930s, utilize cellular components during their replication cycle. Lipids play important roles in viral infection, as coronaviruses target cellular lipids and lipid metabolism to modify their host cells to become an optimal environment for viral replication. Therefore, lipids can be considered as potential targets for the development of antiviral agents. This review provides an overview of the roles of cellular lipids in different stages of the life cycle of coronaviruses.
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KEYWORD
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Human coronaviruses, Lipids, Metabolism, SARS-CoV-2
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