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KMID : 1120220230140040272
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Osong Public Health and Research Perspectives
2023 Volume.14 No. 4 p.272 ~ p.278
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Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea
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Kim Jeong-Min
Kim Dong-Ju
Lee Nam-Joo
Woo Sang-Hee
Lee Jae-Hee
Lee Hyeok-Jin
Park Ae-Kyung
Kim Jeong-Ah
Lee Chae-Young
Kim Il-Hwan
Yoo Cheon-Kwon
Kim Eun-Jin
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Abstract
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Objectives : Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owing to the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2. Its Delta and Omicron variants are more transmissible and pathogenic than other variants. Some debates have emerged on the mechanism of variants of concern. In the COVID-19 wave that began in December 2021, the Omicron variant, first reported in South Africa, became identifiable in most cases globally. The aim of this study was to provide data to inform effective responses to the transmission of the Omicron variant.
Methods : The Delta variant and the spike protein D614G mutant were compared with the Omicron variant. Viral loads from 5 days after symptom onset were compared using epidemiological data collected at the time of diagnosis.
Results : The Omicron variant exhibited a higher viral load than other variants, resulting in greater transmissibility within 5 days of symptom onset.
Conclusion : Future research should focus on vaccine efficacy against the Omicron variant and compare trends in disease severity associated with its high viral load.
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KEYWORD
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Omicron variant, SARS-CoV-2, Transmissibility
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