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KMID : 1120220240150020174
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Osong Public Health and Research Perspectives
2024 Volume.15 No. 2 p.174 ~ p.181
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Establishment of a registry of clinical data and bioresources for rare nervous system diseases
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Kim Da-Young
Kim Soo-Young
Seok Jin-Myoung
Shin Kyong-Jin
Oh Eung-Seok
Jeon Mi-Young
Park Joung-Kyu
Chang Hee-Jin
Youn Jin-Young
Oh Jee-Young
Sohn Eun-Hee
Park Jin-Se
Cho Jin-Whan
Kim Byoung-Joon
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Abstract
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Rare diseases are predominantly genetic or inherited, and patients with these conditions frequently exhibit neurological symptoms. Diagnosing and treating many rare diseases is a complex challenge, and their low prevalence complicates the performance of research, which in turn hinders the advancement of therapeutic options. One strategy to address this issue is the creation of national or international registries for rare diseases, which can help researchers monitor and investigate their natural progression. In the Republic of Korea, we established a registry across 5 centers that focuses on 3 rare diseases, all of which are characterized by gait disturbances resulting from motor system dysfunction. The registry will collect clinical information and human bioresources from patients with amyotrophic lateral sclerosis, spinocerebellar ataxia, and hereditary spastic paraplegia. These resources will be stored at ICreaT and the National Biobank of Korea. Once the registry is complete, the data will be made publicly available for further research. Through this registry, our research team is dedicated to identifying genetic variants that are specific to Korean patients, uncovering biomarkers that show a strong correlation with clinical symptoms, and leveraging this information for early diagnosis and the development of treatments.
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KEYWORD
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Data collection, Health resources, Nervous system, Rare diseases
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