KMID : 1128320090070010020
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Electrolytes & Blood Pressure 2009 Volume.7 No. 1 p.20 ~ p.24
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Role of Pendrin in Acid-base Balance
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Chang Jae-Hyun
Kim Se-Joong
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Abstract
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Pendrin (SLC26A4) is a Na£«-independent Cl£/HCO3£ exchanger which is expressed in the apical membranes of type B and non-A, non-B intercalated cells within the distal convoluted tubule, the connecting tubule, and the cortical collecting duct. In those segments it mediates HCO3£ secretion and chloride (Cl£) absorption. In mice, no renal abnormalities are observed under basal conditions, and individuals with genetic disruption of the pendrin (SLC26A4) gene (Pendred syndrome) have normal acid-base balance. In contrast, there are definite differences under conditions wherein the transporter is stimulated. In animal studies, pendrin (SLC26A4) is upregulated with aldosterone analogues, Cl£ restriction, and metabolic alkalosis, and is down-regulated with Cl loading and metabolic acidosis, independently. However, the exact role of pendrin in humans has not been
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KEYWORD
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pendrin, SLC26A4, acidosis, renal tubular, metabolic alkalosis
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