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KMID : 1134820180470121210
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 12 p.1210 ~ p.1216
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Cholesterol and Visceral Fat Lowering Effects of Combined Lactic Acid Bacteria (Lactobacillus casei WK3, Enterococcus faecium WK5, Bifidobacterium longum WK9, and Lactobacillus plantarum K-1) in High Fat Diet-Fed C57BL/6J Mice
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Park Ho-Eun
Do Kyung-Hyo
Jeong Jin-Woong
Jung Yong-Hyun
Lee Wan-Kyu
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Abstract
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We investigated the serum cholesterol and visceral fat lowering effects of combined lactic acid bacteria (Lactobacillus casei WK3, Enterococcus faecium WK5, Bifidobacterium longum WK9, and Lactobacillus plantarum K-1) in high fat diet-fed mice. To investigate the hypocholesterolemic effects of lactic acid bacteria (LAB), six-week old male C57BL/6J high fat-diet fed mice were orally administered WK3 (2.0×109 CFU/mouse) alone or mixed with WK5, WK9 and K-1 (Combined LAB, 5.0×108 CFU/mouse) for 6 weeks. The normal diet control group and high fat-cholesterol diet control group (HFC) were given PBS instead of LAB. After 6 weeks, pathological and biochemical blood analyses were conducted. Upon blood lipid analysis, the levels of total cholesterol and low density lipoprotein cholesterol were significantly decreased in mice in the Combined LAB group (135.2±19.18 and 50.3±0.97 mg/dL, respectively) compared to the HFC group (154.3±15.60 and 64.1±0.73 mg/dL, respectively). However, treatments had no effects on the serum aspartate aminotransferase and alanine aminotransferase levels. In H&E stained liver sections, HFC mice showed accumulation of lipid droplets, but they were rare in livers of Combined LAB fed mice. The increased epididymal adipose tissue of high fat diet-fed mice was significantly reduced by Combined LAB supplementation. These results suggested that administration of Combined LAB had serum cholesterol and visceral fat lowering effects and could be useful probiotics for cholesterol and visceral fat lowering products.
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KEYWORD
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cholesterol, hypercholesterolemia, visceral fat, Lactobacillus casei WK3, Lactobacillus plantarum K-1
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