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KMID : 1137020080190020129
Journal of Gynecologic Oncology
2008 Volume.19 No. 2 p.129 ~ p.134
Original Article : The efficacy of concurrent cisplatin and 5-flurouracil chemotherapy and radiation therapy for Locally advanced cancer of the uterine cervix
Choi Il-Jung

Cha Moon-Seok
Park Eunku-Seul
Han Myoung-Seok
Choi Young-Min
Je Goo-Hwa
Kim Hyun-Ho
Abstract
Objectives: To evaluate the efficacy of concurrent chemoradiation (CCRT) using 5-flurouracil (5-FU) and cisplatin for locally advanced cervical cancer.

Methods: We reviewed the medical records of 57 patients with locally advanced cervical cancer (stage IIB-IVA and bulky IB2-IIA tumor) who underwent the CCRT at Dong-A University Hospital from January 1997 to June 2007. The
CCRT consisted of 5-FU, cisplatin and pelvic radiation. Every three weeks, 75 mg/m2 cisplatin was administered on
the first day of each cycle and 5-FU was infused at the dose of 1,000 mg/m2/d from the second day to the fifth day of
each cycle. Radiation was administered to the pelvis at a daily dose of 1.8 Gy for five days per week until a medium
accumulated dose reached to 50.4 Gy. If necessary, the radiation field was extended to include paraaortic lymph nodes.
Consolidation chemotherapy was performed using 5-FU and cisplatin.

Results: Fifty-seven patients were enrolled and the median follow-up duration was 53 months (range 7-120 months). The overall response rate was 91.5% (74% complete response and 17.5% partial response). The 5-year overall survival and 3-year progression free survival rates were 69.4% and 74.9%, respectively. During the follow-up period (median 23 months, range 7-60 months), fourteen patients were diagnosed as recurrent disease.

Conclusion: CCRT with 5-FU and cisplatin which is the primary treatment for patients with locally advanced cervical
cancer was effective and well tolerated.
KEYWORD
Concurrent chemoradiation, CCRT, Locally advanced cervical cancer, Bulky cervical mass, Cisplatin, 5-fluorouracil
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