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KMID : 1140120060110030199
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Cancer Prevention Research
2006 Volume.11 No. 3 p.199 ~ p.204
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A Study on the Gene Expression Profiles of Nonylphenol-exposed Nematode (Caenorhabditis elegans) Analyzed with Microarray
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Lee Chul-Woo
Hwang Jeong-Won
Jung Hwa-Jin
Seo Young-Rok
Kim Hyun-Mi
Chung Young-Hee
Choi Kyung-Hee
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Abstract
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Endocrine disruptor has been known to be one of potent hazardous chemicals able to disrupt the normal hormone signaling resulting in the development of many diseases including breast cancer. In this study, alterations of gene expression in response to endocrine disruptor nonylphenol were investigated in the nematode (Caenorhabditis elegans) as one of useful alternative animal models using a microarray containing of 22K nematode-specific probes. Upon exposure to nonylphenol for 24 hrs, we found 39 different genes that were significantly up- or down-regulated. Phosphatase, esterase and glutathion-s- transferase genes were up-regulated. In contrast, heat shock protein and connective tissue proteins were down-regulated. Our results indicate that nematode (C. elegans) is susceptible to nonylphenol toxicity and nematode microarray would be a reliable tool to speed up investigation of gene expression profiles after exposure to nonylphenol and other endocrine disruptors.
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KEYWORD
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Nematode, Caenorhabditis elegans, Microarray, Nonylphenol
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