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KMID : 1140320190030040139
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Precision and Future Medicine
2019 Volume.3 No. 4 p.139 ~ p.145
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Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review
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Kim Hye-Been
Kang Jong-Sun
Jeong Hyun-Ju
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Abstract
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Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated in diverse processes, including muscle regeneration and metabolic homeostasis. Reciprocally, loss of skeletal muscle mass and function related to aging or other pathological conditions could be related to the secondary chronic diseases, for example, metabolic syndromes, chronic inflammation, or cardiovascular diseases. Thus, understanding the pathways that regulate muscle homeostasis is critical to develop therapeutic strategies for preventing muscle loss and related secondary chronic diseases. Recent in vivo research using gene-targeting mouse models have advanced our knowledge about the role of several PRMTs in muscle regeneration and metabolic controls. In this review, we will focus on the recent discoveries on the in vivo function of PRMTs in muscle homeostasis.
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KEYWORD
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Muscle, skeletal, Regeneration, Metabolism, Protein arginine methyltransferase
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