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KMID : 1140320200040010021
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Precision and Future Medicine
2020 Volume.4 No. 1 p.21 ~ p.30
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Two-sample Mendelian randomization study for schizophrenia and breast cancer
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Kim So-Yeon
Kim Ki-Won
Myung Woo-Jae
Lee Hye-Won
Kim Ho
Kim Doh-Kwan
Won Hong-Hee
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Abstract
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Purpose: The purpose of this study was to investigate whether the risk of schizophrenia is causally associated with the risk of breast cancer.
Methods: Bidirectional two-sample Mendelian randomization (TSMR) was performed using genome-wide association study summary data from a total of 311,266 individuals. The causal relationship was estimated using an inverse-variance weighted method (IVW). For sensitivity analysis, weighted median, Mendelian randomization (MR)-Egger regression, and Mendelian randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were used.
Results: The study showed evidence of a causal association between schizophrenia and the risk of breast cancer. In the IVW analysis, the odds ratio for breast cancer per log odds increase in schizophrenia risk was 1.069 with a 95% confidence interval of 1.028 to 1.112 (P< 0.001). This liability was consistently observed using multiple sensitivity analyses (P< 0.05). By contrast, the TSMR analysis of an inverted direction revealed no significant impact of breast cancer on the risk of schizophrenia.
Conclusion: Our results suggested that schizophrenia and breast cancer may have shared biological backgrounds. Genetic factors associated with schizophrenia might be causally associated with the risk of breast cancer.
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KEYWORD
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Breast neoplasms, Causality, Genetic background, Genome-wide association study, Schizophrenia
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