KMID : 1140320210050020083
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Precision and Future Medicine 2021 Volume.5 No. 2 p.83 ~ p.89
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Finding the optimal cutoff value for amyloid ¥â positivity using the iterative outlier method and concordance rate
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Kim Hang-Rai
Choe Yeong-Sim Moon Seung-Hwan Kim Hee-Jin Jang Hye-Min Na Duk-L. Park Seong-Beom Seo Sang-Won
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Abstract
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Purpose: The purpose of this study was to calculate the cutoff value for amyloid ¥â (A¥â) positron emission tomography (PET) positivity using the iterative outlier method and to evaluate its validity based on the concordance rate.
Methods: We performed the iterative outlier method on 373 cognitively unimpaired (CU) subjects and calculated the optimal cutoff value for A¥â positivity. The validation was performed using the independent dataset, comprising 83 subjects (27 CU, 27 amnestic mild cognitive impairment, and 29 Alzheimer¡¯s dementia). We evaluated the validity of the A¥â cutoff value by calculating its concordance rate with the visual assessment and between two different A¥â tracers performed in the same subject.
Results: The concordance rate of A¥â cutoff values with the visual assessment ranged from 84.3% to 91.5%, depending on the reference regions. The concordance rate of the cutoff values between the two A¥â tracers ranged from 90.3% to 97.5%, all of which were higher than that of the visual assessment (86.7%).
Conclusion: We demonstrated that the iterative outlier method could identify the cutoff value for A¥â PET positivity.
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KEYWORD
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Alzheimer disease, Amyloid, Positron-emission tomography
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