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KMID : 1140320210050030142
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Precision and Future Medicine
2021 Volume.5 No. 3 p.142 ~ p.148
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Two cases of non-fluent variant primary progressive aphasia with different pathological diagnoses
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Hwangbo Song
Hwang Soo-Hyun
Suh Mee-Kyung
Kim Seung-Joo
Kim Ye-Shin
Kim Hee-Jin
Na Duk-L.
Seo Sang-Won
Suh Yeon-Lim
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Abstract
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Non-fluent variant primary progressive aphasia (nfvPPA), a subtype of frontotemporal lobar dementia syndrome, has been proven to have various pathological diagnoses. A 63-year-old woman and 71-year-old man separately visited our clinic for language dysfunction. Both patients showed non-fluent speech. The female patient showed personality change accompanied by language dysfunction, while the male patient had parkinsonian symptoms such as bradykinesia and cogwheel rigidity. Both patients were clinically diagnosed with nfvPPA. Several years after the first visit, the patients died, and a brain autopsy was performed. On postmortem examination, the female patient was pathologically diagnosed with Pick’s disease, while the male patient was diagnosed with progressive supranuclear palsy. Our report suggests that nfvPPA patients might show distinct clinical features depending on underlying pathologies.
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KEYWORD
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Autopsy, Pick disease of the brain, Primary progressive nonfluent aphasia, Supranuclear palsy, progressive
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