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KMID : 1140520200240020089
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Korean Journal of Emergency Medical Services
2020 Volume.24 No. 2 p.89 ~ p.97
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A study on easy-to-use drug formulation for emergency medical technicians
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Kim Hoon
Kim Chul-Tae
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Abstract
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Purpose: In this study we aimed to manufacture and evaluate an oral disintegrating film containing ibuprofen.
Methods: Optimal oral ventilation was manufactured using ibuprofen 3g, polyvinyl alcohol #500 4.2g, HPMC K 100M 1.6g, glycerol 4g, TWEEN #20 0.3g, PEG #20 0.3g, citric acid 0.5g, sucralose 0.1g, ethamol 10mL, and distilled water 30mL.
Results: Film mass ranged from 110 to 130mg in all prescriptions, showing general uniformity while the water content ranged from 6 to 12%. Measurement of ibuprofen content in all manufactured film solutions averaged 100.12% (98.0-102.0%). The elution test predicted the time taken from the body and the film agent of all prescriptions was released 100% within 5 minutes to confirm the rapid elution.
Conclusion: Based on the results of all test, prescription E was proved to be the most suitable.
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KEYWORD
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Orally disintegrating film, Ibuprofen, Emergency medical technicians, Drug formulation
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