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KMID : 1140620150050040006
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CellMed
2015 Volume.5 No. 4 p.6 ~ p.6
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Study on the Anti-hypertension mechanism of Prunella Vulgaris based on entity grammar systems
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Du Li
Li Man Man
Zhang Bai Xia
He Shuai Bing
Hu Ya Nan
Wang Yun
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Abstract
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Literatures and experimental studies have shown that Prunella has an effect on anti-hypertension, however, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood pressure regulation in. So we decide to systematically study the anti-hypertension mechanism of Prunella. We integrated multiple databases and constructed molecular interaction network between the chemical constituents of Prunella Vulgaris and hypertension based on entity grammar systems model. The network has 262 nodes and 802 edges. Then we infer the interactions between chemical compositions and disease targets to clarify the anti-hypertension mechanism. Finally, we found Prunella could influence hypertension by regulating apoptosis, cell proliferation, blood vessel development and vasoconstriction, etc. Thus this study provides reference for drug development and compatibility, and also gives guidance for health care at a certain extent.
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KEYWORD
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Prunella Vulgaris, hypertension, mechanism, entity grammar systems
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