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KMID : 1140620170070030014
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CellMed
2017 Volume.7 No. 3 p.14 ~ p.14
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Validation of chrysophanol and cordycepin as marker compounds for standardization of a new herbal mixture AST2017-01
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Jang Jae-Bum
Kim Tae-Young
Jeong Hyun-Ja
Kim Hyung-Min
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Abstract
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Rumex crispus (RC) or Cordyceps militaris (CM) has been used traditionally to treat various diseases and has been also consumed as a functional food made by humanitas medicine concept. We prepared a new herbal mixture, AST2017-01 which is mainly composed of processed (Beopje)-RC (P-RC) and -CM (P-CM). This study aims to validate marker compounds (chrysophanol and cordycepin) in P-RC and P-CM and water extracted-RC and -CM using liquid chromatography-tandem mass spectrometry. In addition, we analyzed contents of chrysophanol and cordycepin in AST2017-01. The linarites of chrysophanol and cordycepin were obtained in calibration curve with a coefficient of correlation of 0.999. The results showed that the concentrations of chrysophanol and cordycepin in P-RC and P-CM were almost 1.70 and 1.23 fold higher than that in RC and CM, respectively. Furthermore, contents of chrysophanol and cordycepin in the AST2017-01 are approximately 0.13% and 0.028%, respectively. In conclusion, these results indicate that chrysophanol and cordycepin were validated as marker compounds in the AST2017-01.
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KEYWORD
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Rumex crispus, Cordyceps militaris, liquid chromatography-tandem mass spectrometry, chrysophanol, cordycepin
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