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KMID : 1141120150010010040
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The Nerve
2015 Volume.1 No. 1 p.40 ~ p.43
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Emerging Variant Glioma: Glioblastoma with a Primitive Neuro-Ectodermal Tumor(PNET) Component
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Han Bo-Ram
Choi Hyuk-Jai
Yang Jin-Seo
Kang Suk-Hyung
Cho Yong-Jun
Choi Kyung-Chan
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Abstract
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A 81-year old male with multiple mass lesion of the right fronto-temporo-parietal lobe and right frontal lobe was admitted to our hospital due to hemiparesis. Neuroimaging studies showed ring-enhancing lesions in right fronto-temporo-parietal lobe and right frontal lobe on magnetic resonance imaging (MRI). Tumor tissue evaluated to be consistent with glioblastoma radiologically was subjected to total excision. Using a morphological and immunophenotypic approach, the predominant component of the tumor was found to bear the properties of classic glioblastoma. The other component was composed of undifferentiated areas that exhibiting small cell morphology and diffuse neuronal immunophenotype. The case was diagnosed as ‘Glioblastoma with primitive neuroectodermal tumor (PNET) component’. The patient who had been performed postoperative radiotherapy, showed shrinkage of non-operative lesion and no sign of recurrence and neurological deficit during 12 months follow-up. We report a rare case of glioblastoma with a PNET component that has a relatively favorable outcome following surgery with radiotherapy and then review previous reports.
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KEYWORD
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Glioma, Variant glioma, Glioblastoma, Primitive neuroectodermal tumor
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