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KMID : 1141120160020010001
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The Nerve
2016 Volume.2 No. 1 p.1 ~ p.4
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Treatment Outcome of Gamma Knife Radiosurgery of Vestibular Schwannomas with Cystic Component
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Lee Jung-Min
Kwon Do-Hoon
Kim Chang-Jin
Kim Jeong-Hoon
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Abstract
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Objective: Many studies have shown favorable outcome of Gamma knife radiosurgery (GKRS) for vestibular schwannomas (VSs). However, there have been few studies which have shown the treatment result of cystic VSs (CVSs) for GKRS. The aim of this study was to confirm whether GKRS for CVSs continues to be safe and effective.
Methods: The study population consisted 511 patients (172 males, 339 females) with VSs treated with GKRS between May 1990 and December 2013. Group 1 defined as cyst/tumor volume >30%, group 2 was cyst/tumor volume >50%, and group 3 was solid tumor or cyst/tumor volume ≤30%. To analyze factors that correlated with treatment outcomes, the following factors were assessed: tumor volume, cyst volume, tumor/cyst ratio, cyst type (single vs. multicystic), previous resection history, marginal radiation dose.
Results: The median follow up period was 52 months (range, 12-110 months). Tumor progression in group 1 was 5 (18.5%), group 2 was 1 (11.1%) and group 3 was 31 (6.4%). In group 1, 2 patients underwent delayed microsurgery at 31 and 36 months after GKRS.
Conclusion: In this study we found that GKRS for large CVS was associated with poor treatment outcome. Further study is needed to identify the mechanism of the tumor progression of CVS after GKRS.
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KEYWORD
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Gamma knife, Cystic vestibular schwannoma, Solid vestibular schwannoma
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