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KMID : 1141120200060010001
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The Nerve
2020 Volume.6 No. 1 p.1 ~ p.6
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Effect on Middle Cerebral Artery Blood Flow of Nicardipine Hydrochloride of Acute Intracerebral Hemorrhage: Transcranial Doppler Sonography Study
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Park Jong-Seon
Hwang Sung-Kyun
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Abstract
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Objective: The authors conducted a prospective comparative study to evaluate the effect of intravenous Nicardipine hydrochloride (HCl) on middle cerebral blood flow (CBF) in patients with acute intracerebral hemorrhage (ICH).
Methdos: This study included 46 patients with acute ICH in a single center between May 2013 and December 2014, who were treated using intravenous Nicardipine HCl. The middle cerebral artery flow velocity (MFV) represented by a regional CBF and pulsatility index (PI) were measured using transcranial doppler sonography at admission (baseline), 24 hr and 7 days. The MFV and PI on the affected side were compared with those of the healthy side.
Results: Administration of intravenous Nicardipine HCl resulted in a decrease of mean systolic blood pressure (BP) and diastolic BP. The results demonstrated that lower MFV and higher PI were observed on the affected side than on the healthy side throughout the transcranial doppler ultrasonography study. However, MFV and PI on the affected side were not significantly changed compared with those of the healthy side after intravenous Nicardipine HCl infusion at 24 hr and 7 days (p>0.05).
Conclusion: This study supports the use of intravenous Nicardipine HCl based on the absence of statistically significant CBF changes associated with a reduction of BP after ICH. Further studies are needed in order to investigate whether reduction in BP has an influence on ICH expansion, and CBF dynamics on a larger, controlled, randomized basis to confirm an effect on CBF after antihypertensive drug.
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KEYWORD
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Cerebral hemorrhage, Cerebrovascular circulation, Nicardipine, Ultrasonography, oppler, transcranial
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