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KMID : 1141220150060040353
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Safety and Health at Work
2015 Volume.6 No. 4 p.353 ~ p.356
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A Case-Study of Implementation of Improved Strategies for Prevention of Laboratory-acquired Brucellosis
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Castrodale Louisa J.
Raczniak Gregory A.
Rudolph Karen M.
Chikoyak Lori
Cox Russell S.
Franklin Tricia L.
Traxler Rita M.
Guerra Marta
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Abstract
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Background: In 2012, the Alaska Section of Epidemiology investigated personnel potentially exposed to a Brucella suis isolate as it transited through three laboratories.
Methods: We summarize the first implementation of the United States Centers for Disease Control and Prevention 2013 revised recommendations for monitoring such exposures: (1) risk classification; (2) antimicrobial postexposure prophylaxis; (3) serologic monitoring; and (4) symptom surveillance.
Results: Over 30 people were assessed for exposure and subsequently monitored for development of illness. No cases of laboratory-associated brucellosis occurred. Changes were made to gaps in laboratory biosafety practices that had been identified in the investigation.
Conclusion: Achieving full compliance for the precise schedule of serologic monitoring was challenging and resource intensive for the laboratory performing testing. More refined exposure assessments could inform decision making for follow-up to maximize likelihood of detecting persons at risk while not overtaxing resources.
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KEYWORD
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Alaska, brucellosis, laboratory-acquired infections, laboratory-associated brucellosis, laboratory biosafety
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