|
KMID : 1141220230140010118
|
|
Safety and Health at Work
2023 Volume.14 No. 1 p.118 ~ p.123
|
|
|
The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat
|
|
Maryam Esfahani
Amir Hossein Rahbar
Sara Soleimani Asl
Saed Bashirian
Effat Sadat Mir Moeini
Fereshteh Mehri
|
|
|
Abstract
|
|
|
Background Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease.
Method In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days.
Results Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica.
Conclusion These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.
|
|
|
KEYWORD
|
|
|
Silicosis, Vitamin D, Oxidative stress, Inflammation, TNF-α
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|