|
KMID : 1141720160040010008
|
|
폐쇄성폐질환
2016 Volume.4 No. 1 p.8 ~ p.8
|
|
|
|
|
Kim Woo-Jin
Yang Se-Ran
|
|
|
Abstract
|
|
|
|
Oxidative stress occurs an imbalance between the production of free radical and antioxidant defenses. In healthy, reactive oxygen species, reactive nitrogen species and antioxidants are essential for regulation of cellular homeostasis and physiological signaling. However, the imbalance between oxidants and antioxidants persistently induces oxidative stress and inflammation leading to chronic obstructive pulmonary disease (COPD). In this review, we focus on the general relevances of oxidative stress/antioxidant markers and its involved cellular network in the progression of COPD. Even the variable antioxidants are developed, pre-clinical and clinical studies need to focus on patients with specific COPD-related subphenotypes and identify COPD-specific biomakers during dignosis.
|
|
|
KEYWORD
|
|
|
Oxidative stress, COPD, Antioxidant, Acute exacerbation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|