|
KMID : 1141720160040010009
|
|
폐쇄성폐질환
2016 Volume.4 No. 1 p.9 ~ p.9
|
|
|
|
|
Choi Hye-Sook
|
|
|
Abstract
|
|
|
|
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are caused by bacterial infection, viral infection, air pollutions, and unknown etiologies. The most common cause, approximately 50% of exacerbations in COPD, is bacterial infection. Antibiotics should be used for bacterial exacerbations to prevent overuse, side effects, and resistance emergence. However, in real life field, almost patients with COPD exacerbations are extensively treated with antibiotics regardless of guideline recommendations, because there are no rapid, specific, and precise markers which identify bacterial exacerbations. We review the recent studies that have defined clinical and laboratory markers to distinguish between bacterial and nonbacterial exacerbations. These markers are sputum colors, sputum purulence, C-reactive protein, and procalcitonin, which are readily available. However, they showed the inconsistent associations with bacterial exacerbations. Further investigation will be needed for easy, quick, and precise markers to identify bacterial exacerbations which benefit from antibiotics.
|
|
|
KEYWORD
|
|
|
Acute exacerbation, Antibiotics, COPD
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|