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KMID : 1141720160040020002
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폐쇄성폐질환
2016 Volume.4 No. 2 p.2 ~ p.2
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Kang Hye-Ryun
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Abstract
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Asthma is a heterogeneous chronic airway diseases include various phenotypes and endotypes. Once airway of heathy individuals was considered as sterile. However, it is known that airway is full of commensal and symbiotic microorganisms, i.e. ‘microbiome’. Currently, microbiome has emerged as a missing piece which can explain the pathogenesis of diverse chronic diseases. Microbiome research in asthma has been focused on the association between characteristics of airway microbiome and the development, severity, and treatment response of asthma. Proteobacteria is found to be increased in asthmatic airways but its role in the development and exacerbation of asthma is not clearly validated. More intensive research focused on the functional aspect of microbiome related with inception and exacerbation of asthma according to subtypes based on pathophysiologic features are needed in order to uncover the pathogenesis of asthma.
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KEYWORD
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Airway, Microbiome, Asthma
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