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KMID : 1141720160040020007
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폐쇄성폐질환
2016 Volume.4 No. 2 p.7 ~ p.7
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Kim Deog-Kyeom
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Abstract
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COPD is a chronic airway disease defined with the airflow limitation in spirometry. However, recently it has been regarded as an umbrella term containing heterogeneous clinical, radiographic, and physiological features although pathologic findings of chronic small airway inflammation and parenchymal destruction are predominant findings. Patients with similar level of FEV1 showed various clinical manifestations in the aspect of dyspnea, emphysema extent, exercise capacity etc. Heterogeneous phenotypes and even endotypes of COPD have been identified and characterized through various COPD cohort studies. Therefore, our current knowledge on COPD can’t be discussed without mentioning cohort studies. In this review, the characteristics and their roles of some representative cohorts recruited patients with COPD are briefly described to help to understand the results from those cohorts including Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study, The Genetic Epidemiology of COPD (COPDGene) study, SPIROMICS study, Korean Obstructive Lung Disease study (KOLD), The KOrea COPD Subgroup Study Team Cohort (KOCOSS), and Asian Network of Obstructive Lung Diseases (ANOLD) study.
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KEYWORD
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COPD, cohort, KOLD, KOCOSS
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