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KMID : 1141720160040020010
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폐쇄성폐질환
2016 Volume.4 No. 2 p.10 ~ p.10
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Lee Sang-Ah
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Abstract
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Background: Depletion of endogenous antioxidants and chronic oxidant burden play a key role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Dietary antioxidants have been suggested to have protective role against COPD. The prospective study was conducted to evaluate the effect of dietary antioxidants on the COPD risk and lung function in Korean.
Methods: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES) Cohort. To diagnose the COPD, forced expiratory volume (FEV1) and forced vital capacity (FVC) was measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated food-frequency questionnaire. Multiple logistic regression was examined to evaluate the OR after adjusted for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.
Results: The risk of COPD decreased with increase in the dietary vitamin C intake (ORQ1vs.Q5=0.66, Ptrend=0.03) and vitamin E (ORQ1vs.Q5=0.56, Ptrend=0.05); predominantly, in men (OR=0.61, Ptrend=0.01 for vitamin C; OR=0.54, Ptrend=0.05 for vitamin E). The combined effect of smoking and dietary antioxidant vitamins C or E intake on COPD risk among men were observed.
Conclusions: Our results suggest the independent beneficial effect of antioxidants, particularly vitamins C and E, and the combined effect of smoking and antioxidant vitamins on the risk of COPD and the lung function in men.
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KEYWORD
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Chronic Obstructive Pulmonary Disease (COPD), Antioxidant vitamins intake, Smoking, Lung function, The combined effect of smoking and antioxidant vitamins
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