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KMID : 1141720190070010028
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폐쇄성폐질환
2019 Volume.7 No. 1 p.28 ~ p.31
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Innate Immunity in Asthma
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Kim Byung-Keun
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Abstract
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The immune system consists of innate and adaptive immunity. Conventional immunological mechanisms of asthma have been explained by adaptive immunity, especially type 2 immune response. However, recent studies have shown that innate immunity also contributes to the development and exacerbation of asthma. Innate lymphoid cells (ILCs) which have been actively studied recently are immune cells with characteristics of both innate and adaptive immunity. Among them, the relationship between group 2 ILC and asthma has already been elucidated in many studies. Bronchial epithelial cell and innate cytokines also contribute to the mechanism of asthma. Asthma is a heterogeneous disease which various mechanisms are involved in. These studies concerning innate immunity in asthma can provide comprehensive understanding and contribution to new treatment strategy of asthma.
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KEYWORD
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Innate immunity, Asthma, Innate lymphoid cell
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