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KMID : 1141720190070010032
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폐쇄성폐질환
2019 Volume.7 No. 1 p.32 ~ p.35
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VIII Asthma-COPD Overlap (ACO) Should Be Considered as a Distinct Phenotype?
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Jo Yong-Suk
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Abstract
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In a significant number of chronic airway disease characterized by chronic airflow obstruction, the features of asthma and COPD can be shared, which is called asthma-COPD overlap (ACO). Patients with ACO have more severe symptoms and unfavorable progress compared to asthma or COPD. There is no single unified diagnostic criteria to define ACO, and there is no large scale therapeutic trial for these patients, but recent studies have focused on genetic characteristics, biomarkers, and radiologic features that help distinguish ACO from asthma or COPD. However, it is difficult to regard that ACO is caused by a completely different pathophysiology from asthma or COPD, and there is lack of evidence. Nevertheless, ACO is worthy of recognition as a phenotypic chronic airway disease characterized by airflow obstruction with several clinical features distinct from asthma and COPD. Thus a consensus on international definition of ACO is needed to design further clinical trials to evaluate specific therapeutic interventions.
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KEYWORD
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Asthma-COPD overlap, Chronic airway disease, Phenotype
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