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KMID : 1141720190070020075
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폐쇄성폐질환
2019 Volume.7 No. 2 p.75 ~ p.79
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Role of Microbiome and Nanovesicles in Asthma and COPD
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Yang Jin-Ho
Kim Yoon-Keun
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Abstract
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Through changes in the residential environment, the indoor environment has become contaminated with biological pollutants in the air that can cause immune dysfunction and lung diseases such as asthma and COPD. Severe inflammatory reactions can continuously occur in some cases of inflammatory responses caused by biological factors such as allergens, viruses, and bacterial components. Ultrafine particles in the air are also very significant as they are closely related to health risks. When ultrafine particles are inhaled, they are absorbed not only by the macrophages in the alveoli, but also by airway epithelial cells leading to higher health risk. Therefore, sensitization caused by exposure to bacterial ultrafine dust present in indoor dust should be considered a critical causative factor in the occurrence of asthma, COPD and lung cancer. In order to prevent COPD and lung cancer, it is important to avoid exposure to indoor bacterial pathogens and EVs.
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KEYWORD
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Extracellular vesicle, House dust, COPD, Asthma, Lung cancer
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