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KMID : 1141720200080010017
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폐쇄성폐질환
2020 Volume.8 No. 1 p.17 ~ p.20
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Review on Non-inhaled Medications in COPD
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Rhee Chin-Kook
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Abstract
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Inhaled medication is most important medication in COPD. However, some non-inhaled medications are also effective on COPD. Roflumilast is effective on decreasing exacerbation in patients with history of hospitalization. Recent studies suggest biomarker for effect of roflumilast is blood eosinophil. Azithromycin is also effective on decreasing exacerbation. In post hoc analysis, azithromycin is effective in former smokers. Erdosteine and N-acetylcysteine (NAC) decreased exacerbation in randomized clinical trial. However, erdosteine predominantly decreased mild exacerbation and NAC decreased exacerbation in only moderate COPD patients. Mepolizumab decreased exacerbation only in patients with high blood eosinophil.
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KEYWORD
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Roflumilast, Azithromycin, Erdosteine, N-acetylcysteine, Mepolizumab
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