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KMID : 1141720200080010047
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폐쇄성폐질환
2020 Volume.8 No. 1 p.47 ~ p.53
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Kang Sung-Yoon
Park So-Young
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Abstract
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The hygiene hypothesis was first proposed in 1989 by David Strachan, who observed an inverse correlation between hay fever and the number of older siblings. Reduced family size and subsequent decreased microbial exposure lead to allergic diseases by the defects in the establishment of immune tolerance. Although the hygiene hypothesis in asthma and allergic diseases is supported by epidemiological and immunological evidence, some evidence does not provide unequivocal support for the hygiene hypothesis. In this review, we summarize the recent evidence for and against the ‘hygiene hypothesis’ and identify causal association across studies, along with discussing future research.
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KEYWORD
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Hygiene hypothesis, Asthma, Atopy, Infections
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