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KMID : 1141720220100010001
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폐쇄성폐질환
2022 Volume.10 No. 1 p.1 ~ p.4
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Update of the Preserved Ratio Impaired Spirometry (PRISm)
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Park Hye-Jung
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Abstract
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Preserved ratio impaired spirometry (PRISm) is defined when pulmonary function test shows preserved ratio (forced expiratory volume in 1 second [FEV1]/forced vital capacity [FVC] ratio＞70%) with impaired lung function (predicted FEV1＜80%). Traditionally, this group has been suggested to have restrictive pattern. However, recent studies have revealed that PRISm rarely showed apparent interstitial lung disease. Instead, recent studies showed that PRISm have pre-COPD features. PRISm group showed significant respiratory symptoms similar to COPD. They used COPD medications and visited hospital for respiratory symptoms more frequently compared to normal group. They have poor quality of life (QOL), and old age and low socioeconomic statusy play important roles in poor QOL in PRISm. In addition, they are likely to develop COPD over time. Reduced FVC/TLC ratio is predictive marker for progression to COPD and exacerbation of COPD. Last, PRISm is also associated with increased mortality. However, PRISm is not homogenous disease, there are various clusters in PRISm. They are clinically and genetically heterogeneous. Subjects with PRISm should be carefully monitored for COPD development, especially when they are older or have wheezing.
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KEYWORD
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COPD, FEV1, FVC, PRISm
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FullTexts / Linksout information
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Listed journal information
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