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KMID : 1141720230110010015
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폐쇄성폐질환
2023 Volume.11 No. 1 p.15 ~ p.20
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Natural history of COPD
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Abstract
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Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition with persistent and progressive airflow obstruction. COPD is characterized by chronic respiratory symptoms occurring due to the abnormalities of airways, emphysema, and multiple comorbidities caused by chronic systemic inflammation. Although tobacco smoking is the major environmental risk factor for COPD, other factors including genetic predisposition, prematurity, respiratory infections, childhood asthma, and air pollution account for a considerable proportion of COPD. The development of COPD is explained by a failure to reach the predicted level of peak lung function in early adulthood as well as a rapid decline of lung function after reaching the normal level, suggesting some COPD cases can start early in life and young individuals are affected. Hence, therapeutic measures focusing on early COPD and different phenotypes along with multidisciplinary approaches treating comorbidities are required.
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KEYWORD
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Chronic obstructive pulmonary disease, phenotype, comorbidity
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FullTexts / Linksout information
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Listed journal information
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