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KMID : 1141720230110010031
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폐쇄성폐질환
2023 Volume.11 No. 1 p.31 ~ p.36
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The gut-lung microbiome axis in chronic airway disease
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Abstract
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The gut microbiota plays a crucial role in the development, training, and maintenance of the immune system and in homeostasis. Alterations in the diversity and composition of the gut microbiome, known as dysbiosis, can significantly affect immune responses and disrupt the integrity of the mucosal barrier in the airways. As a result, gut dysbiosis can have a profound impact on the development and progression of chronic airway diseases. Recent research suggests that this relationship between the gut and lungs, coined the gut?lung axis, may be a key for the treatment of chronic airway disease through targeted manipulation of the gut microbiota. Although our understanding of this connection is still evolving, emerging evidence highlights the potential therapeutic benefits of modulating the gut microbiota in the context of lung diseases. This review focuses on recently discovered interactions between the gut microbiota and the lungs and their influence on asthma and chronic obstructive pulmonary disease (COPD). We also hypothesize that the gut microbiome could be an important therapeutic target for asthma and COPD.
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KEYWORD
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gut-lung axis, microbiome, asthma, chronic obstructive pulmonary disease
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FullTexts / Linksout information
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Listed journal information
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