|
KMID : 1141720230110010043
|
|
폐쇄성폐질환
2023 Volume.11 No. 1 p.43 ~ p.51
|
|
|
Biomarkers in Asthma: Integrated utilization with treatable traits
|
|
|
|
|
Abstract
|
|
|
Asthma is a diagnosis that comprehensively refers to various disease conditions with heterogeneous pathogenic mechanisms, but there is still a lack of solid confirmation of treatments focused on heterogeneity. Stratification of asthmatic patients based on combined biomarkers and treatable traits and linking them to individualized treatments can be a potentially useful approach to precision medicine for better outcomes. Although current several guidelines consider the use of biomarkers including serum eosinophil count and fractional exhaled nitric oxide, this incorporation of partial precision medicine into a traditional step-ladder therapeutic approach still has remained unsatisfactory. To apply more active and preemptive precision medicine to asthma management, identifying each patient's biomarkers and treatable traits is an essential task. Recent advances in big data management and -omics science, where knowledge of asthma has grown significantly, enable a deeper understanding of the underlying molecular pathways guiding precision medicine through the
identification of biomarkers and treatable traits.
|
|
|
KEYWORD
|
|
|
Biomarker, Treatable traits, Omics, Asthma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|