|
KMID : 1143220210640040353
|
|
Obstetrics & Gynecology Science
2021 Volume.64 No. 4 p.353 ~ p.363
|
|
|
Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial
|
|
Rahnemaei Fatemeh Alsadat
Gholamrezaei Ali
Afrakhteh Maryam
Zayeri Farid
Vafa Mohammad Reza
Rashidi Arian
Ozgoli Giti
|
|
|
Abstract
|
|
|
Objective: Recent studies have shown a possible association between vitamin D deficiency and the severity of primary dysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemic symptoms in patients with primary dysmenorrhea.
Methods: This double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years with primary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IU of vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes were pain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), and severity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12).
Results: Compared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity (?1.0 and ?1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (?1.0 day at weeks 4 and 8, P<0.001), the number of consumed pain-relief medications (?1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (?1.0 score at weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes.
Conclusion: Vitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemic symptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.
|
|
|
KEYWORD
|
|
|
Dysmenorrhea, Vitamin D, Cholecalciferol, Pain
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|