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KMID : 1143620140180020048
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Korean Journal of Nuclear Medicine Technology
2014 Volume.18 No. 2 p.48 ~ p.56
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Study on Glomerular Filtration Rate comparison according to renal depth measurement of kidney donors
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Lee Han-Wool
Park Min-Soo
Kang Chun-Koo
Cho Seok-Won
Kim Joo-Yeon
Kwon Oh-Jun
Lim Han-Sang
Kim Jae-Sam
Park Hoon-Hee
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Abstract
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Purpose : 99m Tc-DTPA renal scintigraphy serves as a key indicator to measure a kidney donor's Glomerular Filtration Rate (GFR) and determine the possibility of kidney transplant. The Gates method utilized to measure GFR considers
3 variables of renal depth, injection dose, and net kidney counts. In this research, we seek to compare changes
in kidney donors' GFR according to renal depth measurement methods of the 3 variables.
Materials and Methods : We investigated 32 kidney donors who had visited the hospital from October, 2013 to March, 2014 and received abdominal CT and 99mTc-DTPA GFR examination. With the cross-section image of the CT and the lateral image from a gamma camera, we measured the renal depth and compared with renal depth calculation equationsTonnesen, Taylor, and Itoh methods. Renal depth-specific GFR was calculated by using Xeleris Ver. 2.1220 of
GE. Then the results were compared with MDRD (Modification of Diet Renal Disease) GFRs based on serum
creatinine level.
Results : The renal depths measured based on the CT and gamma camera images showed high correlation. Tonessen
equation gave the lowest GFR value while the value calculated by using the renal depth of CT image was the highest with a 16.62% gap. MDRD GFR showed no statistically significant difference among values calculated through Taylor, Itoh, CT and gamma camera renal depth application (P>0.05), but exhibited a statistically significant change in the value based on Tonnesen equation (P<0.05).
Conclusion : This research has found that, in GFR evaluation in kidney donors by utilizing 99mTc-DTPA, Tonnesen equation-based Gates method underestimated the value than the MDRD GFR. Therefore, if a MDRD GFR value
shows a huge difference from the actual examination value, using an image-based renal depth measurement, instead of Tonnesen equation applied to Gates method, is expected to give an accurate GFR value to kidney donors.
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KEYWORD
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Renal Depth, GFR, Gates Method, MDRD
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