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KMID : 1143620190230010064
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Korean Journal of Nuclear Medicine Technology
2019 Volume.23 No. 1 p.64 ~ p.68
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Studies on sterile filters in the preparation of N-13 ammonia injection
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Oh Chang-Bum
Kim Si-Hwal
Cha Min-Jung
Shin Jin
Ji Yong-Gi
Choi Sung-Ook
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Abstract
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Purpose: In the preparation process for N-13 Ammonia injections, there were radioactive medicines adsorbed on filters remarkably. Hereby, we have compared the adsorption rate and quality test on Millex GS filter and Satorious Minisart filter, both representatively hydrophilic sterilizing filters, also evaluated which filter is more accommodative for N-13 Ammonia injection.
Materials and Methods: The filters used for sterilization of N-13 Ammonia injections were Millex GS filter(0.22 μm) mand Satorious Minisart filter (0.2 μm), which are generally used to strain aqueous solutions. After the N-13 Ammonia passes through each sterilization filter, the adsorption rate of the filter (n=10) is determined by measuring not only the radioactivity through the filter also the amount of radioactivity remaining in it using a Dose Calibrator. The N-13 Ammonia injections after each filter is tested by the quality control test to conform to the Samsung Medical Center standard.
Results: The ratio of radioactivity passed through Millex GS indicated 29.0 ± 17.6%. Satorious Minisart filters output was 80.9 ± 3.2%, respectively. Each ratio of radioactivity adsorbed on the sterile filter was 71.0 ± 17.6% for Millex GS and 19.1 ± 3.2% for the Satorious Minisart filters, respectively. Furthermore, on the ratio of filtered radioactivity, Using Satorious Minisart filter showed about 2.8 times higher than using Millex GS filter. The quality testing of N-13 Ammonia injections through each filter met the Samsung Medical Center standard.
Conclusion: The Millex GS filter is composed of cellulose acetate and cellulose nitrate, whereas the Satorious Minisart filter if composed only of cellulose acetate. Therefore, the presence of cellulose nitrate in the membrane seems to have made differences. Therefore, the use of Satorious Minisart filter in the preparation of N-13 Ammonia injection solution minimized the loss of radioactive medicines due to filter adsorption, thereby improving the synthesis yield.
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KEYWORD
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N-13 ammonia, sterile filter, CAD
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