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KMID : 1143620190230020038
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Korean Journal of Nuclear Medicine Technology
2019 Volume.23 No. 2 p.38 ~ p.42
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The Quantitative Evaluation of Cardiac Calcification Using 18F-Sodium fluoride PET/CT
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Choi Yong-Hoon
Lee Seung-Jae
Kang Chun-Koo
Lim Han-Sang
Kim Jae-Sam
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Abstract
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Purpose: Although computed tomography (CT) is used for coronary artery calcification, it is difficult to differentiate between high risk microcalcifications. Studies have shown that 18F-sodium fluoride (18F-NaF) is very useful for the diagnosis of microcalcifications. In this study, we aimed to evaluate the usefulness of 18F-NaF PET imaging in quantitative evaluation of calcification.
Materials and Methods: A total of 45 patients (67.1 ± 6.9 years old) were injected with 250 MBq of 18F-NaF for 1 hour and images were acquired for 30 minutes. All patients underwent CT angiography (CTAngiography, CTA) before the PET scan.
The SUVmax of calcification was measured and the background radioactivity of the left atrium was measured to determine Target to Background (TBR) and quantitatively analyzed. High risk group was classified through ROC curve (Receiver Operating Characteristic Curve).
Results: There were 226 coronary artery calcifications in the cohort and SUVmax was 1.15 ± 0.39. Of the 28 patients (62%), 58 were classified as high risk (TBR > 1.25). The remaining 168 were TBR ≤ 1.25.
Conclusion 18F-NaF PET images were available for quantitative assessment of microcalcifications and could be classified into high-risk groups. The combination of angiographic CT and 18F-NaF PET may be a new method for early diagnosis of high-risk microcalcifications.
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KEYWORD
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18F-NaF, CT angiography (CTA), SUVmax, Target to Background (TBR)
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