|
KMID : 1147720110040040236
|
|
Journal of Acupuncture and Meridian Studies
2011 Volume.4 No. 4 p.236 ~ p.241
|
|
|
Ayurvedic Formulation of Liv-Pro-08 Reduces Nonalcoholic Fatty Liver Disease in Rats Fed with High-fat Diet
|
|
Vedanarayanan M. Suriyavathana
Krishnan Nandhini
|
|
|
Abstract
|
|
|
|
Nonalcoholic fatty liver disease (NAFLD) has emerged as a serious obesity-related disorder, and it will continue to be a major liver health issue worldwide in the coming decades. We aimed to determine the effect of Liv-Pro-08 (Nigella sativa, Entada pursaetha, and Ficus glomerata) an oral ayurvedic formulation on rats fed with high-fat diet. Rats were given a high-fat diet for a period of 7 days. After this period, Liv-Pro-08 (250, 500, and 750 mg/kg.body weight was given orally for 7 days. We examined the effect of the high-fat diet on various parameters related to obesity and insulin resistance. In the experimental rats who received the extract of Liv-Pro-08, their lipoprotein profiles were significantly improved compared with those that are not receiving the extract. Also, a slight reduction was observed in serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzymes. Moreover, Liv-Pro-08 significantly decreased their fasting serum glucose and fasting insulin levels. This experimental study suggests that Liv-Pro-08 can act as a therapeutic tool in preventing NAFLD progression (i.e., reducing hepatic lipid accumulation). Although further investigations and large randomized trials should be conducted, ayurvedic Liv-Pro-08 oral formulation may be a potential natural drug for NAFLD in the future.
|
|
|
KEYWORD
|
|
|
lipid profiles, LIV-Pro-08, liver marker enzymes, NAFLD, nonalcoholic fatty liver disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|