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KMID : 1147920180010010011
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Medical Biological Science and Engineering
2018 Volume.1 No. 1 p.11 ~ p.17
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Anti-oxidant, skin whitening, and antibacterial effects of Canavalia gladiata extracts
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Kim Ho-Chan
Moon Hae-Gang
Jeong Yeong-Cheol
Park Jung-Up
Kim Young-Ran
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Abstract
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Canavalia gladiata, a Chinese medicine known as sword bean, has been traditionally used for anti-inflammatory and anti-oxidant properties. This study evaluated the pharmacologic effects of C. gladiata on anti-oxidant, skin whitening, and antibacterial activities. The 80% ethanol extracts were prepared from ripe or unripe C. gladiata. We also made activity comparison between ripe and unripe C. gladiata. DPPH and nitro blue tetrazolium/xanthine oxidase (XO) assays were used to evaluate the anti-oxidant activity. C. gladiata showed antioxidant effect in a dose dependent manner. Next, mushroom tyrosinase activity was measured to evaluate the skin whitening effect. C. gladiata showed inhibitory effect on tyrosinase activity in a dose dependent manner. C. gladiata extracts also inhibited XO activity. In addition, the antibacterial effects were evaluated by using the minimum inhibitory concentration test and disk diffusion assay. C. gladiata showed antibacterial activity to Vibrio vulnificus. In conclusion, C. gladiata showed the anti-oxidant, tyrosinase inhibition, and antibacterial activities. C. gladiata extracts may be useful for the development of skin whitening and anti-bacterial agents.
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KEYWORD
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Canavalia gladiata, Anti-oxidant, Skin whitening, Anti-bacterial
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