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KMID : 1147920220050020052
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Medical Biological Science and Engineering
2022 Volume.5 No. 2 p.52 ~ p.56
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A short review of adverse events of sugammadex
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Son Hyo-Jung
Jeong Uk-Jin
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Abstract
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Sugammadex is a specific reversal agent that causes fast and reliable recovery from aminosteroidal non-depolarizing neuromuscular blocking agents. In addition, sugammadex does not cause muscarinic side effects that occur while using existing acetylcholinesterase inhibitors, and it is increasingly used in clinical practice despite its high price. However, with the accumulation of clinical experience, side effects such as hypersensitivity, anaphylaxis, tachycardia, severe bradycardia, hypotension, cardiac arrest, incomplete reversal, negative pressure pulmonary edema, coagulation disorder, steroid interaction, hypermagnesemia, hypothermia, vomiting, dry mouth, and nerve damage, are known to occur, and other adverse negative reactions have been reported. As BRIDION®’s patent on sugammadex expires, generic products having lower prices are pouring into the market, and it is expected that these products will be used by anesthesiologist in clinical practice more than now. This review article focuses on the things that an anesthesiologist must keep in mind before using sugammadex widely.
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KEYWORD
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Adverse effects, Neuromuscular blocker, Neuromuscular reversal, Sugammadex
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