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KMID : 1147920240070010028
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Medical Biological Science and Engineering
2024 Volume.7 No. 1 p.28 ~ p.34
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Inhibition of morphological change and phagocytosis by grape seed extracts in LPS-stimulated mouse macrophages
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Lee Yun-Hyeong
Lee Min-Young
Jeon Young-Jin
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Abstract
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In this study, we observed the inhibition of lipopolysaccharide (LPS)-stimulated shape changes in mouse macrophages by grape seed extract (GSE). Upon stimulation with LPS, macrophages typically exhibited pseudopodia formation, including lamellipodia and filopodia, along with an increase in size; meanwhile, unstimulated cells maintained their round morphology. GSE effec tively impeded these LPS-induced morphological changes and phagocytosis. To investigate the mechanisms of the inhibitory action of GSE on macrophage activation, we investigated its im pact on mitogen-activated protein kinase (MAPK). Although GSE did not significantly inhibit JNK, one of the three MAPK family members, it exerted notable inhibitory effects on p38 and ERK1/2.
In summary, GSE demonstrated potent efficacy in restraining both phagocytosis and morpho logical transformation of macrophages. Given the centrality of these kinases in inflammatory signals, GSE has emerged as a promising candidate for anti-inflammatory interventions.
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KEYWORD
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Macrophages, Phagocytosis, Grape seed extracts, Lamellipodia, Filopodia
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