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KMID : 1148020130380010020
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조선대학교의대논문집
2013 Volume.38 No. 1 p.20 ~ p.22
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De novo Acute Myeloid Leukemia with JAK2 V617F: A Case Report
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Kim Woo-Sung
Park Gyun-Cheol
Kang Sung-Ho
Park Chi-Young
Jang Sook-Jin
Moon Dae-Soo
Park Geon
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Abstract
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JAK2 V617F mutation is a common event in chronic myeloproliferative disorders. However, de novo acute myeloid leukemiawith JAK2 V617F is rarely encountered. The authors report the case of a 74-year-old male with de novo acute myeloblasticleukemia without maturation (AML M1) and a JAk2 V617F heterozygotic mutation. Despite treatment with standardAML regimens, the patient died 2 months after a diagnosis of acute leukemia. This case of an AML patient with a JAK2V617F mutation with a poor prognosis suggests that despite its rarity, a JAK2 V617F mutational study be considered forprognostic purposes in AML.
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KEYWORD
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AML, M1, JAK2, V617F
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