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KMID : 1148020130380030136
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조선대학교의대논문집
2013 Volume.38 No. 3 p.136 ~ p.138
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Successful Treatment with Capecitabine after a History of 5-Fluorouracil Induced Encephalopathy in a Patient with Rectal Cancer
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Shin Jin-Ho
Jeong Yeon-Sang
Cho Jin-Kyeong
Kim Min-Sung
Park Sung-Jae
Jun Hyun-Jung
Oh So-Yeon
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Abstract
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Capecitabine is a prodrug of a 5-fluorouracil (5-FU) that is converted to 5-FU inside the tumor cells. Here, we report a caseof 5-FU induced encephalopathy which was subsequently treated with capecitabine without any neurologic complication. A76-year-old man with rectal adenocarcinoma received chemotherapy, which consisted of 5-FU, leucovorin and oxaliplatinafter resection of the primary and metastatic masses. Confusion and agitation were observed during the 2nd cycle of chemotherapyand reappeared during 4th cycle. Both events were completely disappeared within a few days. Capecitabine wasadministered for 4 cycles without any neurologic toxicity. Capecitabine could be an alternative in patients experiencing 5-FUinduced encephalopathy.
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KEYWORD
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5-Fluorouracil, Capecitabine, Hyperammonemic encephalopathy, Rectal cancer
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