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KMID : 1148020140390010039
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조선대학교의대논문집
2014 Volume.39 No. 1 p.39 ~ p.42
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Paraneoplastic Neutrophilia Originating from an Anaplastic Transformation of Papillary Thyroid Carcinoma in a Metastatic Pleural Lesion
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Baek Jeong-Su
Lee Sung-Hyun
Cho Ae-Ri
Lee Joo-Young
Jang Jeong-Mi
Lee Seung-Suk
Lee Hyo-Rak
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Abstract
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Marked neutrophilia associated with neoplasia is a relatively rare finding and has been considered as a paraneoplastic manifestation.Thyroid cancer seldom presents with paraneoplastic leukocytosis. We report on a case of a 69-year-old man whopresented with paraneoplastic leukocytosis seven months after undergoing total thyroidectomy and I-131 therapy for treatmentof papillary thyroidcarcinoma. We found neither bone marrow involvement of malignant cells nor hematologic malignancy.Based on elevated levels of serum granulocyte colony-stimulating factor, we concluded that the cause was paraneoplasticleukocytosis. Another interesting point was the anaplastic transformation in the pleural metastatic site. It usuallyoccurs in the intrathyroid or regional lymph node.
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KEYWORD
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Paraneoplastic leukocytosis, Anaplastic carcinoma, Papillary thyroid carcinoma, Anaplastic transformation, Granulocyte colony-stimulating factor
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