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KMID : 1148020140390040324
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조선대학교의대논문집
2014 Volume.39 No. 4 p.324 ~ p.326
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Efficacy of Steroid Treatment in Logopenic Variant Primary Progressive Aphasia with Sjogren's Syndrome
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Park Woon-Yeong
Kim Sang-Hoon
Park Sang-Hag
Seo Eun-Hyun
Kim Seung-Gon
il Ju-Chang
Choo Il-Han
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Abstract
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Primary progressive aphasia (PPA) is a progressive degenerative disorder that primarily affects language. Although the etiology of PPA has not been determined, autoimmune mechanism is known to be one possible pathophysiology. We investigate efficacy of steroid treatment in a patient diagnosed as both logopenic variant PPA and Sjogren's syndrome. After steroid treatment, her cognitive function, especially language ability showed improvement. And also, FDG-PET showed metabolic increase in the bilateral temporal lobe. However, on reassessment after stopping steroid treatment, her cognitive performance declined to pretreatment level.
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KEYWORD
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Primary progressive aphasia, Sjogren's syndrome, Steroid treatment
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