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KMID : 1148020150400030101
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조선대학교의대논문집
2015 Volume.40 No. 3 p.101 ~ p.107
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Clinical Characteristics of Patients with Positive of Anti Ganglioside Antibody
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Chung Ji-Yeon
Choo In-Sung
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Abstract
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Guillain-Barre syndrome can be classified with several subtypes along with the union of each symptom. Autoimmune mechanism is accepted for pathogenesis. It is often difficult to predict the causative antibodies of the various types of Guillain-Barre syndrome, because there are considerable mismatches of causative antibody to clinical phenotype as well as phenotype or antibody heterogeneities. We investigated the clinical characteristics of the patients with positivity of anti-gangliosides antibody in the serum. Nineteen patients were enrolled who showed the positivity of anti-GM1 antibody, anti-GQ1b antibody and anti-GD1b antibody, who had visited the department of neurology of Chosun University Hospital. We classified the three patient groups; 8 patients had positivity for anti-GM1 antibody, 10 patients for anti-GQ1b antibody and 8 patients for GD1b antibody. The result of statistical analysis showed no clinical difference within the groups. Therefore, prediction of causative autoantibody can be risky when we considered only the symptoms and course of disease of Guillain-Barre syndrome.
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KEYWORD
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Guillain-Barre syndrome, Fisher syndrome, Anti-gangliosides antibody
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